Recombinant人HNF-4-alpha protein (ab114232)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP41235
    • 种属Human
    • 序列NDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEM LLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRP
    • 分子量37 kDa including tags
    • 氨基酸324 to 423

技术指标

Our Abpromise guarantee covers the use of ab114232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • FLJ39654
    • FRTS4
    • Hepatic nuclear factor 4 alpha
    • Hepatocyte nuclear factor 4
    • Hepatocyte nuclear factor 4 alpha
    • Hepatocyte nuclear factor 4-alpha
    • HNF 4
    • HNF 4 alpha
    • HNF-4-alpha
    • HNF4
    • HNF4A
    • HNF4A_HUMAN
    • HNF4a7
    • HNF4a8
    • HNF4a9
    • Hnf4alpha
    • HNF4alpha10/11/12
    • MODY
    • MODY 1
    • MODY1
    • NR2A1
    • NR2A21
    • Nuclear receptor subfamily 2 group A member 1
    • OTTHUMP00000031060
    • OTTHUMP00000031062
    • TCF
    • TCF 14
    • TCF-14
    • TCF14
    • Tcf4
    • Transcription factor 14, hepatic nuclear factor
    • Transcription factor 14
    • Transcription factor HNF 4
    • Transcription factor HNF-4
    • Transcription factor HNF4
    see all
  • 功能Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
  • 疾病相关Defects in HNF4A are the cause of maturity-onset diabetes of the young type 1 (MODY1) [MIM:125850]; also symbolized MODY-1. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR2 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 翻译后修饰Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human HNF-4-alpha protein 图像

  • 12.5% SDS-PAGE showing ab114232 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human HNF-4-alpha protein (ab114232)参考文献

ab114232 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114232.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"