High mobility group (nonhistone chromosomal) protein 2
High mobility group box 2
High mobility group protein 2
High mobility group protein B2
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).
Belongs to the HMGB family. Contains 2 HMG box DNA-binding domains.