Recombinant人HMGA1a / HMGA1b protein (ab109927)

概述

  • 产品名称Recombinant人HMGA1a / HMGA1b protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP17096
    • 种属Human
    • 序列MSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSE VPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLEKEEEEGISQ ESSEEEQLEH HHHHH
    • 分子量13 kDa including tags
    • 氨基酸1 to 107
    • 标签His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab109927 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab109927 is purified using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 50% Glycerol, 0.02% DTT, 0.32% Tris HCl, 1.12% Sodium chloride

常规信息

  • 别名
    • High mobility group AT hook 1
    • High mobility group AT-hook protein 1
    • High mobility group protein A1
    • High mobility group protein HMG-I/HMG-Y
    • High mobility group protein R
    • HMG-I(Y)
    • HMGA 1a
    • HMGA 1b
    • HMGA1
    • HMGA1_HUMAN
    • HMGI
    • HMGI/Y
    • HMGR
    • HMGY
    see all
  • 功能HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.
  • 疾病相关Note=A chromosomal aberration involving HMGA1 is found in pulmonary chondroid hamartoma. Translocation t(6;14)(p21;q23-24) with RAD51L1.
  • 序列相似性Belongs to the HMGA family.
    Contains 3 A.T hook DNA-binding domains.
  • 翻译后修饰Constitutively phosphorylated on two or three sites. Phosphorylated upon DNA damage, probably by ATM or ATR. Hyperphosphorylated at early stages of apoptosis, followed by dephosphorylation and methylation, which coincides with chromatin condensation. Isoform HMG-Y can be phosphorylated by HIPK2.
    HMG-Y is not methylated.
    Methylation at Arg-58 is mutually exclusive with methylation at Arg-60.
  • 细胞定位Nucleus. Chromosome.
  • Information by UniProt

Recombinant Human HMGA1a / HMGA1b protein 图像

  • 15% SDS-PAGE showing ab109927 at approximately 12.7 kDa (3µg).

Recombinant Human HMGA1a / HMGA1b protein (ab109927)参考文献

ab109927 has not yet been referenced specifically in any publications.

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