Recombinant人HMG14 protein (ab117159)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionP05114
    • 种属Human
    • 序列MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD LEHHHHHH
    • 分子量12 kDa including tags
    • 氨基酸1 to 100
    • 标签His tag C-Terminus
    • 额外的序列信息HMGN1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 108 amino acids (1-100 a.a.) and having a molecular mass of 11.7 kDa.

技术指标

Our Abpromise guarantee covers the use of ab117159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab117159 was purified by standard chromatography and filter sterilized.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.02% DTT, 0.58% Sodium chloride, 0.003% PMSF, 20% Glycerol

常规信息

  • 别名
    • FLJ27265
    • FLJ31471
    • High mobility group (nonhistone chromosomal) protein 14
    • High mobility group nucleosome binding 1
    • High mobility group nucleosome binding domain 1
    • High mobility group nucleosome binding domain containing protein 1
    • High mobility group nucleosome-binding domain-containing protein 1
    • High mobility group protein 14
    • HMG 14
    • HMG14
    • HMGN 1
    • HMGN1
    • HMGN1_HUMAN
    • MGC104230
    • MGC117425
    • Non-histone chromosomal protein HMG-14
    • Nonhistone chromosomal protein HMG 14
    • Nonhistone chromosomal protein HMG14
    see all
  • 功能Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
  • 序列相似性Belongs to the HMGN family.
  • 翻译后修饰Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
  • 细胞定位Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
  • Information by UniProt

Recombinant Human HMG14 protein (ab117159)参考文献

ab117159 has not yet been referenced specifically in any publications.

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