The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
生物活性useful for Antibody Production and Protein Array
补充说明useful for Antibody Production and Protein Array
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
High mobility group (nonhistone chromosomal) protein 14
High mobility group nucleosome binding 1
High mobility group nucleosome binding domain 1
High mobility group nucleosome binding domain containing protein 1
High mobility group nucleosome-binding domain-containing protein 1
High mobility group protein 14
Non-histone chromosomal protein HMG-14
Nonhistone chromosomal protein HMG 14
Nonhistone chromosomal protein HMG14
功能Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
序列相似性Belongs to the HMGN family.
翻译后修饰Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
细胞定位Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.