Recombinant人HMG14 protein (ab112301)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP05114
    • 种属Human
    • 序列MPKRKVSSTEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDKSSDKKV QTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
    • 分子量37 kDa
    • 氨基酸1 to 100
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab112301 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced

常规信息

  • 别名
    • FLJ27265
    • FLJ31471
    • High mobility group (nonhistone chromosomal) protein 14
    • High mobility group nucleosome binding 1
    • High mobility group nucleosome binding domain 1
    • High mobility group nucleosome binding domain containing protein 1
    • High mobility group nucleosome-binding domain-containing protein 1
    • High mobility group protein 14
    • HMG 14
    • HMG14
    • HMGN 1
    • HMGN1
    • HMGN1_HUMAN
    • MGC104230
    • MGC117425
    • Non-histone chromosomal protein HMG-14
    • Nonhistone chromosomal protein HMG 14
    • Nonhistone chromosomal protein HMG14
    see all
  • 功能Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
  • 序列相似性Belongs to the HMGN family.
  • 翻译后修饰Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
  • 细胞定位Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
  • Information by UniProt

Recombinant Human HMG14 protein 图像

  • ab112301 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human HMG14 protein (ab112301)参考文献

ab112301 has not yet been referenced specifically in any publications.

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