Recombinant人HIPK1 protein (ab60867)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human
    • 氨基酸156 to 555

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技术指标

Our Abpromise guarantee covers the use of ab60867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Hipk 1
    • Hipk1
    • HIPK1_HUMAN
    • Homeodomain interacting protein kinase 1
    • Homeodomain interacting protein kinase 1 like protein
    • Homeodomain-interacting protein kinase 1
    • Myak
    • Nbak 2
    • Nbak2
    • Nuclear body associated kinase 2
    • Nuclear body associated kinase 2b
    see all
  • 功能May play a role as a corepressor for homeodomain transcription factors. Phosphorylates DAXX in response to stress, and mediates its translocation from the nucleus to the cytoplasm. May be involved in malignant squamous cell tumor formation.
  • 组织特异性Ubiquitously expressed with highest levels in skeletal muscle and heart. Overexpressed in breast cancer cell lines.
  • 序列相似性Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated. Phosphorylated and activated by JNK1.
  • 细胞定位Nucleus. Cytoplasm. Predominantly nuclear.
  • Information by UniProt

Recombinant human HIPK1 protein 图像

  • Sample Kinase Activity Plot.
  • ab60867 on SDS-PAGE, MW ~71 kDa.

Recombinant human HIPK1 protein (ab60867)参考文献

ab60867 has not yet been referenced specifically in any publications.

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