Recombinant人HEXIM1 protein (ab117163)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionO94992
    • 种属Human
    • 序列MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAE PFLSEYQHQP QTSNCTGAAA VQEELNPERP PGAEERVPEE DSRWQSRAFP QLGGRPGPEG EGSLESQPPP LQTQACPESS CLREGEKGQN GDDSSAGGDF PPPAEVEPTP EAELLAQPCH DSEASKLGAP AAGGEEEWGQ QQRQLGKKKH RRRPSKKKRH WKPYYKLTWE EKKKFDEKQS LRASRIRAEM FAKGQPVAPY NTTQFLMDDH DQEEPDLKTG LYSKRAAAKS DDTSDDDFME EGGEEDGGSD GMGGDGSEFL QRDFSETYER YHTESLQNMS KQELIKEYLE LEKCLSRMED ENNRLRLESK RLGGDDARVR ELELELDRLR AENLQLLTEN ELHRQQERAP LSKFGD
    • 分子量45 kDa including tags
    • 氨基酸1 to 359
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117163 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    ab117163 was purified by proprietary chromatographic techniques and filter sterilized.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.58% Sodium chloride, 10% Glycerol, 0.32% Tris HCl

常规信息

  • 别名
    • Cardiac lineage protein 1
    • CLP 1
    • CLP1
    • EDG 1
    • EDG1
    • Estrogen down-regulated gene 1 protein
    • FLJ13562
    • Hexamethylene bis acetamide inducible 1
    • Hexamethylene bis acetamide inducible protein
    • Hexamethylene bis acetamide inducible transcript 1
    • Hexamethylene bis-acetamide-inducible protein 1
    • HEXI1_HUMAN
    • HEXIM 1
    • Hexim1
    • HEXIM1 protein
    • HIS 1
    • HIS1
    • HMBA inducible
    • MAQ 1
    • MAQ1
    • Menage a quatre 1
    • Menage a quatre protein 1
    • Protein HEXIM1
    see all
  • 功能Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.
  • 组织特异性Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues.
  • 序列相似性Belongs to the HEXIM family.
  • 结构域The coiled-coil domain mediates oligomerization.
  • 细胞定位Nucleus. Cytoplasm. Binds alpha-importin and is mostly nuclear.
  • Information by UniProt

Recombinant Human HEXIM1 protein (ab117163)参考文献

ab117163 has not yet been referenced specifically in any publications.

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