The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
useful for Antibody Production and Protein Array
Best use within three months from the date of receipt of this protein.useful for Antibody Production and Protein Array
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Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00 Constituents: 0.79% Tris HCl, 0.31% Glutathione Note: Glutathione is reduced
Class B basic helix-loop-helix protein 39
Hairy and enhancer of split 1
Hairy and enhancer of split 1 (Drosophila)
Hairy homolog (Drosophila)
Hairy, Drosophila, homolog of
Hairy/enhancer of split, Drosophila, homolog of, 1
Hes1 hairy and enhancer of split 1 (Drosophila)
Transcription factor HES-1
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity.
Has a particular type of basic domain (presence of a helix-interrupting proline) that binds to the N-box (CACNAG), rather than the canonical E-box (CANNTG). The C-terminal WRPW motif is a transcriptional repression domain necessary for the interaction with Groucho/TLE family members, transcriptional corepressors recruited to specific target DNA by Hairy-related proteins. The bHLH, as well as cooperation between the central Orange domain and the C-terminal WRPW motif, is required for transcriptional repressor activity.