Recombinant人HDAC7 protein (ab101660)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus
  • 氨基酸序列
    • AccessionQ8WUI4
    • 种属Human
    • 分子量80 kDa including tags
    • 氨基酸501 to 952

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技术指标

Our Abpromise guarantee covers the use of ab101660 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab101660 was determined to be 80 RLU/min/ng.
  • 应用

    Functional Studies

    Western blot

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • DKFZP586J0917
    • FLJ99588
    • HD 7a
    • HD7
    • HD7a
    • HDAC 7
    • HDAC 7A
    • Hdac7
    • HDAC7_HUMAN
    • HDAC7A
    • Histone deacetylase 7
    • Histone deacetylase 7A
    • OTTHUMP00000202813
    • OTTHUMP00000202814
    see all
  • 功能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene.
  • 序列相似性Belongs to the histone deacetylase family. HD type 2 subfamily.
  • 结构域The nuclear export sequence mediates the shuttling between the nucleus and the cytoplasm.
  • 翻译后修饰May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import.
  • 细胞定位Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and may be due to its phosphorylation.
  • Information by UniProt

Recombinant human HDAC7 protein 图像

  • SDS-PAGE showing ab101660 at approximately 80kDa.
  • The Specific activity of ab101660 was determined to be 80 RLU/min/ng.

Recombinant human HDAC7 protein (ab101660)参考文献

ab101660 has not yet been referenced specifically in any publications.

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