Recombinant人HDAC6 protein (ab42632)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属
      Human

技术指标

Our Abpromise guarantee covers the use of ab42632 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    Activity: 50 U/ug. One U =1 pmol/min, Assay condition: 25 mM Tris/Cl, pH8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 30 uM Biomol substrate (Catalog number KI177), and 5 ng/ul HDAC6. Incubation condition: 60 min at 30ºC.
  • 应用

    Inhibition Assay

  • 形式
    Liquid
  • 补充说明
    Expressed in a Baculovirus infected Sf9 cell expression system.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on Dry Ice. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 10% Glycerol, 50mM Tris HCl, 20mM Glutathione, 138mM Sodium chloride, pH 8

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • CPBHM
    • FLJ16239
    • HD 6
    • HD6
    • HDAC 6
    • HDAC6
    • HDAC6_HUMAN
    • Histone deacetylase 6
    • Histone deacetylase 6 (HD6)
    • JM 21
    • JM21
    • KIAA0901
    • OTTHUMP00000032398
    • OTTHUMP00000197663
    • PPP1R90
    • Protein phosphatase 1 regulatory subunit 90
    see all
  • 功能
    Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
  • 序列相似性
    Belongs to the histone deacetylase family. HD type 2 subfamily.
    Contains 1 UBP-type zinc finger.
  • 翻译后修饰
    Ubiquitinated. Its polyubiquitination however does not lead to its degradation.
    Sumoylated in vitro.
  • 细胞定位
    Nucleus. Cytoplasm. It is mainly cytoplasmic, where it is associated with microtubules.
  • Information by UniProt

文献

ab42632 has not yet been referenced specifically in any publications.

客户评价及客户问答

Recombinant human HDAC6 protein (ab42632) has a GST tag at N-terminal end.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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