Recombinant人HDAC3 protein (ab101663)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus
  • 氨基酸序列
    • AccessionO15379
    • 种属Human
    • 分子量83 kDa including tags
    • 氨基酸1 to 428

技术指标

Our Abpromise guarantee covers the use of ab101663 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Specific activity 125 RLU/min/ng.
  • 应用

    SDS-PAGE

    Functional Studies

  • 纯度> 70 % SDS-PAGE.
    ab101663 is >70% pure as assessed by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • HD3
    • HDAC 3
    • HDAC3
    • HDAC3_HUMAN
    • Histone deacetylase 3
    • RPD3
    • RPD3 2
    • RPD3-2
    • SMAP45
    see all
  • 功能Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
  • 组织特异性Widely expressed.
  • 序列相似性Belongs to the histone deacetylase family. HD type 1 subfamily.
  • 翻译后修饰Sumoylated in vitro.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant human HDAC3 protein 图像

  • The specific activity of ab101663 was determined to be 125 RLU/min/ng.
  • The purity of HDAC3 was determined to be >70% as assessed by densitometry.
    The approximate molecular weight is ~83 kDa.

Recombinant human HDAC3 protein (ab101663)参考文献

ab101663 has not yet been referenced specifically in any publications.

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