This product is an active protein and may elicit a biological response in vivo, handle with caution.
germ cell associated 2
Germ cell-specific gene 2 protein
Haploid germ cell-specific nuclear protein kinase
Serine/threonine-protein kinase haspin
功能Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.
组织特异性Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily. Contains 1 protein kinase domain.
翻译后修饰Autophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.