Recombinant人Haspin protein (ab104026)

概述

  • 产品名称Recombinant人Haspin protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionQ8TF76
    • 种属Human
    • 分子量64 kDa including tags
    • 氨基酸470 to 798

技术指标

Our Abpromise guarantee covers the use of ab104026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab104026 was determined to be 18 nmol/min/mg.
  • 应用

    Functional Studies

    Western blot

  • 纯度> 75 % SDS-PAGE.
    Purity was determined to be >75% by densitometry.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 10mM Glutathione, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • germ cell associated 2
    • Germ cell-specific gene 2 protein
    • GSG2
    • H-haspin
    • Haploid germ cell-specific nuclear protein kinase
    • HASP_HUMAN
    • Serine/threonine-protein kinase haspin
    see all
  • 功能Required for normal alignment of chromosomes at metaphase. Phosphorylates histone H3 'Thr-3' during mitosis.
  • 组织特异性Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
  • 序列相似性Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Haspin subfamily.
    Contains 1 protein kinase domain.
  • 翻译后修饰Autophosphorylated on both serine and threonine residues (By similarity). Phosphorylated during mitosis. Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant human Haspin protein 图像

  • SDS-PAGE showing ab104026 at approximately 64kDa.
  • The Specific activity of ab104026 was determined to be 18 nmol/min/mg.

Recombinant human Haspin protein (ab104026)参考文献

ab104026 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"