概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MRGSHHHHHHGMASMTGGQQMGRDLYDDDDKDRWGSMLPRLICINDYEQH AKSVLPKSIYDYYRSGAN DEETLADNIAAFSRWKLYPRMLRNVAETDL STSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMML SSW ATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVD TPYLGNRLDDVRNRFKLPPQLR MKNFETSTLSFSPEENFGDDSGLAAY VAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILV SNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALAL GAKAVFVGRPIVWGLAFQGEKGVQDV LEILKEEFRLAMALSGCQNVKV IDKTLVRKNPLAVSKI
    • 分子量
      45 kDa including tags
    • 氨基酸
      1 to 370
    • 标签
      His tag N-Terminus , DDDDK tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113144 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 质谱法
    MALDI-TOF
  • 纯度
    > 95 % SDS-PAGE.
    ab113144 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 2.92% Sodium chloride

常规信息

  • 别名
    • (S) 2 hydroxy acid oxidase
    • Glycolate oxidase
    • GOX
    • GOX1
    • HAO1
    • HAOX1
    • HAOX1_HUMAN
    • Hydroxyacid oxidase 1
    • MGC142225
    • MGC142227
    • OTTHUMP00000030231
    see all
  • 功能
    Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.
  • 组织特异性
    Liver.
  • 通路
    Organic acid metabolism; glycolate degradation; 3-phospho-D-glycerate from glycolate: step 1/4.
  • 序列相似性
    Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
    Contains 1 FMN hydroxy acid dehydrogenase domain.
  • 细胞定位
    Peroxisome.
  • Information by UniProt

Recombinant Human HAO1 protein 图像

  • 15% SDS-PAGE analysis of ab113144 (3µg)

Recombinant Human HAO1 protein (ab113144)参考文献

This product has been referenced in:
  • Wang M  et al. High throughput cell-based assay for identification of glycolate oxidase inhibitors as a potential treatment for Primary Hyperoxaluria Type 1. Sci Rep 6:34060 (2016). Read more (PubMed: 27670739) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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