Recombinant人GRK2 protein (ab125620)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • AccessionP25098
    • 种属Human
    • 分子量102 kDa including tags
    • 氨基酸2 to 689
    • 标签GST tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab125620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The specific activity of ab125620 was determined to be 5.3 nmol/mg/min.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 形式Liquid
  • 补充说明

    ab204876 (Cdc25C peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • ADRBK1
    • Adrenergic beta receptor kinase 1
    • ARBK1_HUMAN
    • BARK
    • BARK1
    • Beta adrenergic receptor kinase 1
    • Beta ARK 1
    • Beta ARK1
    • Beta-adrenergic receptor kinase 1
    • Beta-ARK-1
    • FLJ16718
    • G protein coupled receptor kinase 2
    • G-protein coupled receptor kinase 2
    • GRK2
    see all
  • 功能Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
  • 组织特异性Expressed in peripheral blood leukocytes.
  • 序列相似性Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • Information by UniProt

Recombinant human GRK2 protein 图像

  • The specific activity of ab125620 was determined to be 5.3 nmol/mg/min by Kinase Assay.
  • SDS-PAGE analysis of ab125620.

Recombinant human GRK2 protein (ab125620)参考文献

ab125620 has not yet been referenced specifically in any publications.

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