Recombinant人GRK2 protein (ab125620)

概述

描述

  • 性质
    Recombinant
  • 来源
    Baculovirus infected Sf9 cells
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 分子量
      102 kDa including tags
    • 氨基酸
      2 to 689
    • 标签
      GST tag N-Terminus

相关产品

技术指标

Our Abpromise guarantee covers the use of ab125620 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性
    The specific activity of ab125620 was determined to be 5.3 nmol/mg/min.
  • 应用

    Western blot

    Functional Studies

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明

    ab204876 (Cdc25C peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 7.50
    Constituents: 0.31% Glutathione, 0.002% PMSF, 0.004% DTT, 0.79% Tris HCl, 0.003% EDTA, 25% Glycerol, 0.88% Sodium chloride

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • ADRBK1
    • Adrenergic beta receptor kinase 1
    • ARBK1_HUMAN
    • BARK
    • BARK1
    • Beta adrenergic receptor kinase 1
    • Beta ARK 1
    • Beta ARK1
    • Beta-adrenergic receptor kinase 1
    • Beta-ARK-1
    • FLJ16718
    • G protein coupled receptor kinase 2
    • G-protein coupled receptor kinase 2
    • GRK2
    see all
  • 功能
    Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner.
  • 组织特异性
    Expressed in peripheral blood leukocytes.
  • 序列相似性
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 1 PH domain.
    Contains 1 protein kinase domain.
    Contains 1 RGS domain.
  • Information by UniProt

图片

  • The specific activity of ab125620 was determined to be 5.3 nmol/mg/min by Kinase Assay.
  • SDS-PAGE analysis of ab125620.

文献

ab125620 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab125620.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册