Recombinant人GRHPR protein (ab95913)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL
    • 分子量
      38 kDa including tags
    • 氨基酸
      1 to 328
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab95913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF-TOF
  • 纯度
    > 95 % SDS-PAGE.
    ab95913 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: 20% Glycerol, 0.2M Sodium chloride, 5mM DTT, 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • GLXR
    • glycerate 2 dehydrogenase
    • GLYD
    • Glyoxylate reductase/hydroxypyruvate reductase
    • Grhpr
    • GRHPR_HUMAN
    • OTTHUMP00000021379
    • OTTHUMP00000021380
    • OTTHUMP00000046131
    • PH 2
    • PH2
    • Primary hyperoxaluria type 2
    see all
  • 功能
    Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • 组织特异性
    Ubiquitous. Most abundantly expressed in the liver.
  • 疾病相关
    Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
  • 序列相似性
    Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab95913 at approximately 37.8kDa (3µg).

文献

ab95913 has not yet been referenced specifically in any publications.

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