Recombinant人GRHPR protein (ab119159)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ9UBQ7
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MRPVRLMKVF VTRRIPAEGR VALARAADCE VEQWDSDEPI PAKELERGVA GAHGLLCLLS DHVDKRILDA AGANLKVIST MSVGIDHLAL DEIKKRGIRV GYTPDVLTDT TAELAVSLLL TTCRRLPEAI EEVKNGGWTS WKPLWLCGYG LTQSTVGIIG LGRIGQAIAR RLKPFGVQRF LYTGRQPRPE EAAEFQAEFV STPELAAQSD FIVVACSLTP ATEGLCNKDF FQKMKETAVF INISRGDVVN QDDLYQALAS GKIAAAGLDV TSPEPLPTNH PLLTLKNCVI LPHIGSATHR TRNTMSLLAA NNLLAGLRGE PMPSELKL
    • 分子量38 kDa including tags
    • 氨基酸1 to 328
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab119159 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.
    ab119159 is purified by proprietary chromatographic techniques.
  • 形式Liquid
  • 补充说明Please prevent freeze thaw cycles.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at -20°C. Store under Desiccating conditions.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 1.17% Sodium chloride, 0.08% DTT, 20% Glycerol

常规信息

  • 别名
    • GLXR
    • glycerate 2 dehydrogenase
    • GLYD
    • Glyoxylate reductase/hydroxypyruvate reductase
    • Grhpr
    • GRHPR_HUMAN
    • OTTHUMP00000021379
    • OTTHUMP00000021380
    • OTTHUMP00000046131
    • PH 2
    • PH2
    • Primary hyperoxaluria type 2
    see all
  • 功能Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.
  • 组织特异性Ubiquitous. Most abundantly expressed in the liver.
  • 疾病相关Defects in GRHPR are the cause of hyperoxaluria primary type 2 (HP2) [MIM:260000]; also known as primary hyperoxaluria type II (PH2). HP2 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L-glycerate.
  • 序列相似性Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
  • Information by UniProt

Recombinant Human GRHPR protein (ab119159)参考文献

ab119159 has not yet been referenced specifically in any publications.

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