The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab85917 was purified using conventional chromatography.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 30% Glycerol, 20mM Tris HCl, pH 8.0
Abundant SRC homology
Adapter protein GRB2
Epidermal growth factor receptor binding protein
Epidermal growth factor receptor binding protein GRB2
GRB2 adapter protein
Growth factor receptor bound protein 2
Growth factor receptor bound protein 3
Growth factor receptor-bound protein 2
SH2/SH3 adapter GRB2
功能Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
序列相似性Belongs to the GRB2/sem-5/DRK family. Contains 1 SH2 domain. Contains 2 SH3 domains.
结构域The SH3 domains mediate interaction with RALGPS1 and SHB.