Recombinant人GRB2 protein (ab85917)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV

技术指标

Our Abpromise guarantee covers the use of ab85917 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

  • 纯度> 95 % SDS-PAGE.
    ab85917 was purified using conventional chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 30% Glycerol, 20mM Tris HCl, pH 8.0

常规信息

  • 别名
    • Abundant SRC homology
    • Adapter protein GRB2
    • ASH
    • Ash protein
    • EGFRBP GRB2
    • Epidermal growth factor receptor binding protein
    • Epidermal growth factor receptor binding protein GRB2
    • GRB 2
    • Grb2
    • GRB2 adapter protein
    • GRB2_HUMAN
    • Grb3 3
    • Growth factor receptor bound protein 2
    • Growth factor receptor bound protein 3
    • Growth factor receptor-bound protein 2
    • HT027
    • MST084
    • MSTP084
    • NCKAP2
    • OTTHUMP00000166096
    • OTTHUMP00000166097
    • OTTHUMP00000166098
    • Protein ash
    • SEM5
    • SH2/SH3 adapter GRB2
    see all
  • 功能Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.
    Isoform GRB3-3 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform GRB3-3 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.
  • 序列相似性Belongs to the GRB2/sem-5/DRK family.
    Contains 1 SH2 domain.
    Contains 2 SH3 domains.
  • 结构域The SH3 domains mediate interaction with RALGPS1 and SHB.
  • 细胞定位Golgi apparatus.
  • Information by UniProt

Recombinant Human GRB2 protein 图像

  • 15% SDS-PAGE showing ab85917 at approximately 27kDa (3µg).

Recombinant Human GRB2 protein (ab85917)参考文献

ab85917 has not yet been referenced specifically in any publications.

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