Recombinant人GRASP65 protein (ab112424)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9BQQ3
    • 种属Human
    • 序列MGLGVSAEQPAGGAEGFHLHGVQENSPAQQAGLEPYFDFIITIGHSRLNK ENDTLKALLKANVEKPVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASV RFCSFRRASEQVWHVLDVEPSSPAALAGLRPYTDYVVGSDQILQESEDFF TLIESHEGKPLKLMVYNSKSDSCREVTVTPNAAWGGEGSLGCGIGYGYLH RIPTQPPSYHKKPPGTPPPSALPLGAPPPDALPPGPTPEDSPSLETGSRQ SDYMEALLQAPGSSMEDPLPGPGSPSHSAPDPDGLPHFMETPLQPPPPVQ RVMDPGFLDVSGISLLDNSNASVWPSLPSSTELTTTAVSTSGPEDICSSS SSHERGGEATWSGSEFEVSFLDSPGAQAQADHLPQLTLPDSLTSAASPED GLSAELLEAQAEEEPASTEGLDTGTEAEGLDSQAQISTTE
    • 分子量74 kDa including tags
    • 氨基酸1 to 440

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技术指标

Our Abpromise guarantee covers the use of ab112424 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    ELISA

    Western blot

  • 形式Liquid
  • 补充说明Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • FLJ23443
    • Golgi peripheral membrane protein p65
    • Golgi phosphoprotein 5
    • Golgi reassembly and stacking protein 1
    • Golgi reassembly and stacking protein 65 kDa
    • Golgi reassembly and stacking protein, 65-kD
    • Golgi reassembly stacking protein 1
    • Golgi reassembly stacking protein 1 65kDa
    • Golgi reassembly stacking protein of 65 kDa
    • Golgi reassembly-stacking protein 1
    • Golgi reassembly-stacking protein of 65 kDa
    • GOLPH 5
    • GOLPH5
    • Gorasp 1
    • GORASP1
    • GORS1_HUMAN
    • GRASP 65
    • GRASP65
    • MGC118894
    • MGC118897
    • P65
    see all
  • 功能Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes.
  • 序列相似性Belongs to the GORASP family.
    Contains 1 PDZ (DHR) domain.
  • 翻译后修饰Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher order oligomers, leading to cisternal unstacking.
    Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis.
  • 细胞定位Golgi apparatus > cis-Golgi network membrane. Undergoes rapid exchange with the cytosol.
  • Information by UniProt

Recombinant Human GRASP65 protein 图像

  • ab112424 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human GRASP65 protein (ab112424)参考文献

ab112424 has not yet been referenced specifically in any publications.

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