Recombinant人GPD1L protein (ab113595)

概述

  • 产品名称Recombinant人GPD1L protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ8N335
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMAAAPLKVCIVGSGNWGSAVAKIIGNNVKK LQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSN LSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEG LKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFK ELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVI RLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFA RTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQI CYESRPVQEMLSCLQSHPEHT
    • 分子量41 kDa including tags
    • 氨基酸1 to 351
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113595 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 95 % SDS-PAGE.
    ab113595 was purified using conventional chromatography.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol, 0.02% DTT

常规信息

  • 别名
    • 2210409H23Rik
    • D9Ertd660e
    • Glycerol 3 phosphate dehydrogenase 1 like
    • Glycerol 3 phosphate dehydrogenase 1 like protein
    • Glycerol-3-phosphate dehydrogenase 1-like protein
    • GPD 1L
    • GPD1-L
    • gpd1l
    • GPD1L_HUMAN
    • KIAA0089
    • RGD1560123
    see all
  • 功能Play a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.
  • 组织特异性Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs.
  • 疾病相关Defects in GPD1L are the cause of Brugada syndrome type 2 (BRS2) [MIM:611777]. BRS2 is an autosomal dominant tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.
    Defects in GPD1L are a cause of sudden infant death syndrome (SIDS) [MIM:272120]. SIDS is the sudden death of an infant younger than 1 year that remains unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of clinical history. Pathophysiologic mechanisms for SIDS may include respiratory dysfunction, cardiac dysrhythmias, cardiorespiratory instability, and inborn errors of metabolism, but definitive pathogenic mechanisms precipitating an infant sudden death remain elusive.
  • 序列相似性Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.
  • 细胞定位Cytoplasm. Localized to the region of the plasma membrane.
  • Information by UniProt

Recombinant Human GPD1L protein 图像

  • 15% SDS-PAGE analysis of ab113595 (3µg)

Recombinant Human GPD1L protein (ab113595)参考文献

ab113595 has not yet been referenced specifically in any publications.

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