Recombinant人gp340 protein (ab114867)

概述

  • 产品名称Recombinant人gp340 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ9UGM3
    • 种属Human
    • 序列DYSCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQ LEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHS ITRRGFRAE
    • 分子量38 kDa including tags
    • 氨基酸1377 to 1485

技术指标

Our Abpromise guarantee covers the use of ab114867 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Apactin
    • CRP
    • CRP-[a]
    • CRP-[b]
    • CRP-ductin
    • Crpd
    • DBMT1
    • Deleted in malignant brain tumors 1
    • Deleted in malignant brain tumors 1 protein
    • DMBT 1
    • DMBT1
    • DMBT1 prototype precursor
    • DMBT1/6kb.1 protein precursor
    • DMBT1/8kb.1 protein
    • DMBT1/8kb.2 protein precursor
    • DMBT1_HUMAN
    • Ebnerin
    • FLJ61058
    • Glycoprotein 300
    • Glycoprotein 340
    • Gp 340
    • Gp-340
    • gp300
    • GP340
    • Gp340 variant protein
    • Hensin
    • MGC164738
    • Mucin-like glycoprotein
    • Muclin
    • OTTHUMP00000020654
    • OTTHUMP00000020655
    • OTTHUMP00000020656
    • OTTHUMP00000020657
    • OTTHUMP00000020658
    • OTTHUMP00000020659
    • OTTHUMP00000020660
    • OTTHUMP00000020661
    • OTTHUMP00000020662
    • OTTHUMP00000020663
    • p80
    • Pancrin
    • SAG
    • Salivary agglutinin
    • Surfactant pulmonary associated D binding protein
    • Surfactant pulmonary associated protein D binding protein
    • Surfactant pulmonary-associated D-binding protein
    • Vomeroglandin
    see all
  • 功能May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell.
  • 组织特异性Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract.
  • 疾病相关Defects in DMBT1 are involved in the development of glioma (GLM) [MIM:137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.
  • 序列相似性Belongs to the DMBT1 family.
    Contains 2 CUB domains.
    Contains 14 SRCR domains.
    Contains 1 ZP domain.
  • 发展阶段Expressed in fetal lung, intestine and skin. Secreted to the extracellular matrix (ECM) in certain fetal epithelia.
  • 结构域The SRCR domains mediate binding to bacteria. The minimal bacterial-binding site is an 11-residue repeat of GRVEVLYRGSW where VEVL and W are critical residues.
  • 翻译后修饰Highly N- and O-glycosylated. The O-glycans are heavily sulfated.
  • 细胞定位Secreted. Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae.
  • Information by UniProt

Recombinant Human gp340 protein 图像

  • ab114867 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.

Recombinant Human gp340 protein (ab114867)参考文献

ab114867 has not yet been referenced specifically in any publications.

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