The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA)
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Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
pH: 8.00 Constituents: 0.32% Tris HCl, 20% Glycerol
Glycine N methyltransferase
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
Abundant in liver.
Defects in GNMT are the cause of glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
Belongs to the glycine N-methyltransferase family.