Recombinant人GNMT protein (ab117693)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ14749
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD
    • 分子量35 kDa including tags
    • 氨基酸1 to 295
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117693 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Liquid
  • 补充说明For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA)
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 20% Glycerol

常规信息

  • 别名
    • EC 2.1.1.20
    • Glycine N methyltransferase
    • Glycine N-methyltransferase
    • Gnmt
    • GNMT_HUMAN
    • OTTHUMP00000016412
    see all
  • 功能Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
  • 组织特异性Abundant in liver.
  • 疾病相关Defects in GNMT are the cause of glycine N-methyltransferase deficiency (GNMT deficiency) [MIM:606664]; also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
  • 序列相似性Belongs to the glycine N-methyltransferase family.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant Human GNMT protein (ab117693)参考文献

ab117693 has not yet been referenced specifically in any publications.

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