Recombinant人Glutaredoxin 5 protein (ab117649)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ86SX6
    • 种属Human
    • 序列MGSSHHHHHH SSGLVPRGSH MSGSLGRAAA ALLRWGRGAG GGGLWGPGVR AAGSGAGGGG SAEQLDALVK KDKVVVFLKG TPEQPQCGFS NAVVQILRLH GVRDYAAYNV LDDPELRQGI KDYSNWPTIP QVYLNGEFVG GCDILLQMHQ NGDLVEELKK LGIHSALLDE KKDQDSK
    • 分子量19 kDa including tags
    • 氨基酸1 to 157
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab117649 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

  • 纯度> 85 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 0.58% Sodium chloride, 20% Glycerol

常规信息

  • 别名
    • C14orf87
    • Chromosome 14 open reading frame 87
    • FLB4739
    • GLRX 5
    • Glrx5
    • GLRX5_HUMAN
    • Glutaredoxin 5 homolog
    • Glutaredoxin related protein 5
    • Glutaredoxin-related protein 5
    • Glutaredoxin5
    • GRX5
    • MGC14129
    • mitochondrial
    • Monothiol glutaredoxin-5
    • PRO1238
    see all
  • 功能Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Required for normal iron homeostasis. Required for normal regulation of hemoglobin synthesis by the iron-sulfur protein ACO1.
  • 疾病相关Defects in GLRX5 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA) [MIM:205950]. A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus.
  • 序列相似性Belongs to the glutaredoxin family. Monothiol subfamily.
    Contains 1 glutaredoxin domain.
  • 细胞定位Mitochondrion.
  • Information by UniProt

Recombinant Human Glutaredoxin 5 protein (ab117649)参考文献

ab117649 has not yet been referenced specifically in any publications.

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