Recombinant人Glutamate receptor 3 protein (ab114562)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP42263
    • 种属Human
    • 序列SLLGHYKWEKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQ EFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANL
    • 分子量37 kDa including tags
    • 氨基酸151 to 250

相关产品

技术指标

Our Abpromise guarantee covers the use of ab114562 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • AMPA 3
    • AMPA selective glutamate receptor 3
    • AMPA-selective glutamate receptor 3
    • dJ1171F9.1
    • GluA3
    • GLUK3
    • GluR 3
    • GLUR C
    • GLUR K3
    • GluR-3
    • GluR-C
    • GluR-K3
    • GLUR3
    • GLURC
    • Glutamate receptor 3
    • Glutamate receptor C
    • Glutamate receptor ionotrophic AMPA 3
    • Glutamate receptor ionotropic
    • Glutamate receptor subunit 3
    • GRIA 3
    • Gria3
    • GRIA3_HUMAN
    • Ionotrophic Glutamate Receptor
    • MRX94
    see all
  • 功能Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
  • 疾病相关Defects in GRIA3 are the cause of mental retardation X-linked type 94 (MRX94) [MIM:300699]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. MRX94 patients have moderate mental retardation. Other variable features are macrocephaly, seizures, myoclonic jerks, autistic behavior, asthenic body habitus, distal muscle weakness and hyporeflexia.
  • 序列相似性Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily.
  • 翻译后修饰Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-621 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-847 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis.
  • 细胞定位Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
  • Information by UniProt

Recombinant Human Glutamate receptor 3 protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human Glutamate receptor 3 protein (ab114562)参考文献

ab114562 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114562.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"