Recombinant人GLDC protein (ab116757)

概述

  • 产品名称
    Recombinant人GLDC protein
  • 蛋白长度
    Protein fragment

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      AMISIRQEIADIEEGRIDPRVNPLKMSPHSLTCVTSSHWDRPYSREVAAF PLPFMKPENKFWPTIARIDDIYGDQHLVCTCPPMEVYESPFSEQKRASS
    • 分子量
      37 kDa including tags
    • 氨基酸
      922 to 1020

技术指标

Our Abpromise guarantee covers the use of ab116757 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 mg/ml. Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • GCE
    • GCSP
    • GCSP_HUMAN
    • GLDC
    • Glycine cleavage system P protein
    • glycine cleavage system protein P
    • Glycine decarboxylase
    • glycine decarboxylase P protein
    • Glycine dehydrogenase (decarboxylating) mitochondrial
    • Glycine dehydrogenase [decarboxylating], mitochondrial
    • Gycine dehydrogenase (decarboxylating)
    • HYGN1
    • MGC138198
    • MGC138200
    • NKH
    see all
  • 功能
    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
  • 疾病相关
    Defects in GLDC are a cause of non-ketotic hyperglycinemia (NKH) [MIM:605899]; also known as glycine encephalopathy (GCE). NKH is an autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms.
  • 序列相似性
    Belongs to the gcvP family.
  • 细胞定位
    Mitochondrion.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab116757 at approximately 36.52kDa, stained with Coomassie Blue.

文献

ab116757 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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