Recombinant人GilZ / TilZ protein (ab114823)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ99576
    • 种属Human
    • 序列MAQSKLDCRSPVGLDCCNCCLDLAHRSGLQRGSSGENNNPGSPTVSNFRQ LQEKLVFENLNTDKLNSIMRQDSLEPVLRDPCYLINEGICNRNIDQTMLS ILLFFHSASGASVVAIDNKIEQAMDLVKNHLMYAVREEVEILKEQIRELV EKNSQLERENTLLKTLASPEQLEKFQSCLSPEEPAPESPQVPEAPGGSAV
    • 分子量48 kDa including tags
    • 氨基酸1 to 200

技术指标

Our Abpromise guarantee covers the use of ab114823 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • Delta sleep-inducing peptide immunoreactor
    • DIP
    • DSIP immunoreactive leucine zipper protein
    • DSIP-immunoreactive peptide
    • Dsip1
    • Dsipi
    • GILZ
    • Glucocorticoid-induced leucine zipper protein
    • hDIP
    • Protein DIP
    • T22D3_HUMAN
    • TSC-22-like protein
    • TSC-22-related protein
    • TSC-22R
    • TSC22 domain family protein 3
    • TSC22 domain family, member 3
    • TSC22 related inducible leucine zipper 3
    • TSC22D3
    see all
  • 功能Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.
  • 组织特异性Expressed in brain, lung, spleen and skeletal muscle. Lower levels detected in heart and kidney. Not detected in the pancreas. In non-lymphoid tissues, in the absence of inflammation, the major source of constitutive expression is the macrophage lineage. Also expressed in cells from different hemopoietic cell lineages, including bone marrow cells, CD34+ stem cells, mature B- and T-cells, monocytes and granulocytes. Down-regulated in activated macrophages from inflammatory lesions of delayed-type hypersensitivity (DTH) reactions, such as in tuberculosis and in Crohn disease, whereas in Burkitt lymphoma, persists in macrophages involved in the phagocytosis of apoptotic malignant cells.
  • 序列相似性Belongs to the TSC-22/Dip/Bun family.
  • 结构域The leucine-zipper is involved in homodimerization.
  • Information by UniProt

Recombinant Human GilZ / TilZ protein 图像

  • 12.5% SDS-PAGE Stained with Coomassie Blue

Recombinant Human GilZ / TilZ protein (ab114823)参考文献

ab114823 has not yet been referenced specifically in any publications.

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