Recombinant人GGT1 protein (ab114433)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP19440
    • 种属Human
    • 分子量88 kDa including tags
    • 氨基酸1 to 569

技术指标

Our Abpromise guarantee covers the use of ab114433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • CD224
    • D22S672
    • D22S732
    • Gamma glutamyl transpeptidase
    • Gamma glutamyltransferase 1
    • Gamma glutamyltranspeptidase 1
    • Gamma-glutamyltransferase 1
    • Gamma-glutamyltranspeptidase 1 light chain
    • GGT
    • GGT 1
    • GGT1
    • GGT1_HUMAN
    • Glutamyl transpeptidase
    • Glutathione hydrolase 1
    • GTG
    • Leukotriene C4 hydrolase
    • MGC96892
    • MGC96904
    • MGC96963
    • OTTHUMP00000028921
    • OTTHUMP00000197959
    see all
  • 功能Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive.
  • 组织特异性Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
  • 通路Sulfur metabolism; glutathione metabolism.
  • 疾病相关Defects in GGT1 are a cause of glutathionuria (GLUTH) [MIM:231950]; also known as gamma-glutamyltranspeptidase deficiency. It is an autosomal recessive disease.
  • 序列相似性Belongs to the gamma-glutamyltransferase family.
  • 翻译后修饰N-glycosylated on both chains. Contains hexoses, hexosamines and sialic acid residues. Glycosylation profiles tested in kidney and liver tissues reveal the presence of tissue-specific and site-specific glycan composition, despite the overlap in composition among the N-glycans. A total of 36 glycan compositions, with 40 unique structures are observed. Up to 15 different glycans are observed at a single site, with site-specific variation in glycan composition. The difference in glycosylation profiles in the 2 tissues do not affect the enzyme activity.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human GGT1 protein 图像

  • ab114433 analysed on a 12.5% SDS-PAGE gel stained with Coomassie Blue.

Recombinant Human GGT1 protein (ab114433)参考文献

ab114433 has not yet been referenced specifically in any publications.

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