Recombinant人Germinal Center Kinase protein (ab89753)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab89753 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性The Specific activity of ab89753 was determined to be 290 nmol/min/mg.
  • 应用

    SDS-PAGE

    Western blot

    Functional Studies

  • 形式Liquid
  • 补充说明

    ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • B lymphocyte serine/threonine protein kinase
    • B lymphocyte serine/threonine-protein kinase
    • BL44
    • GC kinase
    • GCK
    • Germinal center kinase
    • germinal centre kinase (GC kinase)
    • M4K2_HUMAN
    • Map4k2
    • MAPK/ERK kinase kinase kinase 2
    • MEK kinase kinase 2
    • MEKKK 2
    • Mitogen activated protein kinase kinase kinase kinase 2
    • Mitogen-activated protein kinase kinase kinase kinase 2
    • Rab8 interacting protein
    • Rab8 interacting protein, formerly
    • Rab8-interacting protein
    • RAB8IP
    • RAB8IP, formerly
    see all
  • 功能Enhances MAP3K1 oligomerization, which may relieve amino-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. May play a role in the regulation of vesicle targeting or fusion.
  • 组织特异性Highly expressed in germinal center but not mantle zone B-cells. Also expressed in lung, brain and placenta and at lower levels in other tissues examined.
  • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
    Contains 1 CNH domain.
    Contains 1 protein kinase domain.
  • 细胞定位Cytoplasm. Basolateral cell membrane. Golgi apparatus membrane.
  • Information by UniProt

Recombinant human Germinal Center Kinase protein 图像

  • SDS-PAGE showing ab89753 at approximately 125kDa.
  • Kinase Assay demonstrating specific activity of ab89753.

Recombinant human Germinal Center Kinase protein (ab89753)参考文献

ab89753 has not yet been referenced specifically in any publications.

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