Recombinant人GCAP1 protein (ab117014)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP43080
    • 种属Human
    • 序列MGNVMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSP SASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYD VDGNGCIDRDELLTIIQAIRAINPCSDTTMTAEEFTDTVFSKIDVNGDGE LSLEEFIEGVQKDQMLLDTLTRSLDLTRIVRRLQNGEQDEEGADEAAEAA G
    • 分子量48 kDa including tags
    • 氨基酸1 to 201

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技术指标

Our Abpromise guarantee covers the use of ab117014 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • COD3
    • GCAP
    • GCAP 1
    • Guanylate Cyclase Activating Protein Photoreceptor 1
    • Guanylate cyclase activator 1A
    • Guanylin 1
    • guanylyl cyclase activating protein 1
    • Guanylyl cyclase-activating protein 1
    • GUC1A_HUMAN
    • GUCA
    • GUCA1
    • GUCA1A
    see all
  • 功能Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
  • 组织特异性Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments.
  • 疾病相关Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3) [MIM:602093]. COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs.
  • 序列相似性Contains 4 EF-hand domains.
  • 细胞定位Membrane.
  • Information by UniProt

Recombinant Human GCAP1 protein 图像

  • 12.5% SDS-PAGE showing GCAP1 at approximately 47.52kDa.
    Stained with Coomassie Blue.

Recombinant Human GCAP1 protein (ab117014)参考文献

ab117014 has not yet been referenced specifically in any publications.

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