Recombinant人GATA4 protein (ab112289)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP43694
    • 种属Human
    • 序列ASGASSNSSNATTSSSEEMRPIKTEPGLSSHYGHSSSVSQTFSVSAMSGH GPSIHPVLSALKLSPQGYASPVSQSPQTSSKQDSWNSLVLADSHGDIITA
    • 分子量37 kDa
    • 氨基酸343 to 442

技术指标

Our Abpromise guarantee covers the use of ab112289 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性useful for Antibody Production and Protein Array
  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明useful for Antibody Production and Protein Array
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione

常规信息

  • 别名
    • ASD2
    • GATA 4
    • GATA binding protein 4
    • GATA-binding factor 4
    • gata4
    • GATA4_HUMAN
    • MGC126629
    • Transcription factor GATA 4
    • Transcription factor GATA-4
    • Transcription factor GATA4
    • VSD1
    see all
  • 功能Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development (PubMed:24000169). Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). Acts as a transcriptional activator of ANF in cooperation with NKX2-5 (By similarity). Promotes cardiac myocyte enlargement (PubMed:20081228). Required during testicular development (PubMed:21220346). May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase (PubMed:15734735).
  • 疾病相关Atrial septal defect 2
    Ventricular septal defect 1
    Tetralogy of Fallot
    Atrioventricular septal defect 4
    Testicular anomalies with or without congenital heart disease
    GATA4 mutations can predispose to dilated cardiomyopathy (CMD), a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
  • 序列相似性Contains 2 GATA-type zinc fingers.
  • 翻译后修饰Methylation at Lys-300 attenuates transcriptional activity.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human GATA4 protein 图像

  • ab112289 analysed on a 12.5% SDS-PAGE stained with Coomassie Blue.

Recombinant Human GATA4 protein (ab112289)参考文献

ab112289 has not yet been referenced specifically in any publications.

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