Recombinant人GAS 6 protein (ab114494)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ14393
    • 种属Human
    • 序列VSLRDGEATLEVDGTRGQSEVSAAQLQERLAVLERHLRSPVLTFAGGLPD VPVTSAPVTAFYRGCMTLEVNRRLLDLDEAAYKHSDITAHSCPPVEPAAA
    • 分子量37 kDa including tags
    • 氨基酸622 to 721

技术指标

Our Abpromise guarantee covers the use of ab114494 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 ug/ul.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris buffered saline

常规信息

  • 别名
    • AXL receptor tyrosine kinase ligand
    • AXL stimulatory factor
    • AXLLG
    • AXS F
    • AXSF
    • DKFZp666G247
    • FLJ34709
    • Gas 6
    • GAS-6
    • Gas6
    • GAS6_HUMAN
    • Growth arrest specific 6
    • Growth arrest-specific protein 6
    • Growth-arrest-specific protein 6
    • Growth-arrest-specific protein 6 precursor
    see all
  • 功能Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
  • 组织特异性Plasma. Isoform 1 and isoform 2 are widely expressed. Isoform 1 is the predominant form in spleen.
  • 序列相似性Contains 4 EGF-like domains.
    Contains 1 Gla (gamma-carboxy-glutamate) domain.
    Contains 2 laminin G-like domains.
  • 翻译后修饰Isoform 1 is proteolytically processed after secretion to yield a N-terminal 36 kDa protein and a C-terminal 50 kDa protein including the laminin G-like domains which activates AXL.
    Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant Human GAS 6 protein 图像

  • 12.5% SDS-PAGE showing ab114494 at approximately 36.63kDa stained with Coomassie Blue.

Recombinant Human GAS 6 protein (ab114494)参考文献

ab114494 has not yet been referenced specifically in any publications.

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