Recombinant人gamma Catenin protein (ab114407)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ15151
    • 种属Human
    • 序列MEVMNLMEQPIKVTEWQQTYTYDSGIHSGANTCVPSVSSKGIMEEDEACG RQYTLKKTTTYTQGVPPSQGDLEYQMSTTARAKRVREAMCPGVSGEDSSL LLATQVEGQATNLQRLAEPSQLLKSAIVHLINYQDDAELATRALPELTKL LNDEDPVVVTKAAMIVNQLSKKEASRRALMGSPQLVAAVVRTMQNTSDLD TARCTTSILHNLSHHREGLLAIFKSGGIPALVRMLSSPVESVLFYAITTL HNLLLYQEGAKMAVRLADGLQKMVPLLNKNNPKFLAITTDCLQLLAYGNQ ESKLIILANGGPQALVQIMRNYSYEKLLWTTSRVLKVLSVCPSNKPAIVE AGGMQALGKHLTSNSPRLVQNCLWTLRNLSDVATKQEGLESVLKILVNQL SVDDVNVLTCATGTLSNLTCNNSKNKTLVTQNSGVEALIHAILRAGDKDD ITEPAVCALRHLTSRHPEAEMAQNSVRLNYGIPAIVKLLNQPNQWPLVKA TIGLIRNLALCPANHAPLQEAAVIPRLVQLLVKAHQDAQRHVAAGTQQPY TDGVRMEEIVEGCTGALHILARDPMNRMEIFRLNTIPLFVQPLYSSVENI QRVAAGALCELAQDKEAADAIDAEGASAPLMELLHSRNEGTATYAAAVLF RISEDKNPDYRKRVSVELTNSLFKHDPAAWEAAQSMIPINEPYGDDLDAT YRPMYSSDVPLDPLEMHMDMDGDYPIDTYSDGLRPPYPTADHMLA
    • 分子量108 kDa including tags
    • 氨基酸1 to 745

技术指标

Our Abpromise guarantee covers the use of ab114407 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Western blot

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ARVD 12
    • ARVD12
    • Catenin (cadherin associated protein), gamma 80kDa
    • catenin (cadherin-associated protein) gamma (80kD)
    • Catenin gamma
    • CTNNG
    • Desmoplakin 3
    • Desmoplakin III
    • Desmoplakin-3
    • Desmoplakin3
    • DesmoplakinIII
    • DP 3
    • DP III
    • DP3
    • DPIII
    • gamma catenin
    • Junction plakoglobin
    • JUP
    • OTTHUMP00000164732
    • OTTHUMP00000164735
    • OTTHUMP00000164738
    • PDGB
    • PKGB
    • PLAK_HUMAN
    • PLAKOGLOBIN
    see all
  • 功能Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
  • 疾病相关Defects in JUP are the cause of Naxos disease (NXD) [MIM:601214]. NXD is an autosomal recessive disorder combining diffuse non-epidermolytic palmoplantar keratoderma with arrhythmogenic right ventricular dysplasia/cardiomyopathy and woolly hair.
    Defects in JUP are the cause of familial arrhythmogenic right ventricular dysplasia type 12 (ARVD12) [MIM:611528]; also called arrhythmogenic right ventricular cardiomyopathy 12 (ARVC12). ARVD is an autosomal dominant disease characterized by partial degeneration of the myocardium of the right ventricle, electrical instability, and sudden death. It is clinically defined by electrocardiographic and angiographic criteria; pathologic findings, replacement of ventricular myocardium with fatty and fibrous elements, preferentially involve the right ventricular free wall.
  • 序列相似性Belongs to the beta-catenin family.
    Contains 9 ARM repeats.
  • 细胞定位Cell junction > adherens junction. Cell junction > desmosome. Cytoplasm > cytoskeleton. Membrane. Cytoplasmic in a soluble and membrane-associated form.
  • Information by UniProt

Recombinant Human gamma Catenin protein 图像

  • 12.5% SDS-PAGE analysis of ab114407, stained with Coomassie Blue.

Recombinant Human gamma Catenin protein (ab114407)参考文献

ab114407 has not yet been referenced specifically in any publications.

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