Recombinant人GALNT1 protein (ab117035)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ10472-2
    • 种属Human
    • 序列MRKFAYCKVVLATSLIWVLLDMFLLLYFSECNKCDEKKERGLPAGDVLEP VQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPD VRLEG
    • 分子量38 kDa including tags
    • 氨基酸1 to 105

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技术指标

Our Abpromise guarantee covers the use of ab117035 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    SDS-PAGE

    Western blot

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    Best use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • GALNAC T1
    • GalNAc transferase 1
    • GalNAc-T1
    • GALNT 1
    • GALNT1
    • GALT1_HUMAN
    • Polypeptide GalNAc transferase 1
    • Polypeptide N acetylgalactosaminyltransferase 1
    • Polypeptide N-acetylgalactosaminyltransferase 1 soluble form
    • pp GaNTase 1
    • pp-GaNTase 1
    • Protein UDP acetylgalactosaminyltransferase 1
    • Protein-UDP acetylgalactosaminyltransferase 1
    • UDP GalNAc:polypeptide N acetylgalactosaminyltransferase 1
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1
    • UDP N acetyl alpha D galactosamine:polypeptide N acetylgalactosaminyltransferase 1 (GalNAc T1)
    • UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1
    see all
  • 功能Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7.
  • 组织特异性Widely expressed. Expressed in all tissues tested.
  • 通路Protein modification; protein glycosylation.
  • 序列相似性Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
    Contains 1 ricin B-type lectin domain.
  • 结构域There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding.
    The ricin B-type lectin domain directs the glycopeptide specificity. It is required in the glycopeptide specificity of enzyme activity but not for activity with naked peptide substrates, suggesting that it triggers the catalytic domain to act on GalNAc-glycopeptide substrates.
  • 细胞定位Secreted and Golgi apparatus > Golgi stack membrane.
  • Information by UniProt

Recombinant Human GALNT1 protein 图像

  • 12.5% SDS-PAGE stained with Coomassie Blue showing ab117035 at approximately 37.62 kDa.

Recombinant Human GALNT1 protein (ab117035)参考文献

ab117035 has not yet been referenced specifically in any publications.

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