功能Binds galactosides. Has high affinity for the Forssman pentasaccharide. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. Inhibits cell proliferation. It is a ligand for HAVCR2/TIM3. Induces T-helper type 1 lymphocyte (Th1) death. Isoform Short acts as an eosinophil chemoattractant.
组织特异性Peripheral blood leukocytes and lymphatic tissues. Overexpressed in Hodgkin disease tissue.
序列相似性Contains 2 galectin domains.
结构域Contains two homologous but distinct carbohydrate-binding domains.
细胞定位Cytoplasm. Secreted. May also be secreted by a non-classical secretory pathway.