Recombinant人GALE protein (ab96767)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMAEKVLVTGGAGYIGSHTVLELLEAGYLPV VIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKY SFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFS SSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNA VLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDY DTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQM VQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMC EDLWRWQKQNPSGFGTQA
    • 分子量
      40 kDa including tags
    • 氨基酸
      1 to 348
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab96767 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Mass Spectrometry

    SDS-PAGE

  • 纯度
    > 95 % SDS-PAGE.
    ab96767 is purified using conventional chromatography techniques.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: None
    Constituents: 10% Glycerol, 0.1M Sodium chloride, 5mM DTT, 20mM Tris HCl, 1mM EDTA, pH 8.0

常规信息

  • 别名
    • FLJ95174
    • FLJ97302
    • Galactose 4 epimerase UDP
    • Galactowaldenase
    • galE
    • GALE_HUMAN
    • OTTHUMP00000002991
    • OTTHUMP00000002994
    • OTTHUMP00000037931
    • OTTHUMP00000044857
    • SDR1E1
    • short chain dehydrogenase/reductase family 1E member 1
    • UDP galactose 4 epimerase
    • UDP galactose 4' epimerase
    • UDP glucose 4 epimerase
    • UDP-galactose 4-epimerase
    • UDP-glucose 4-epimerase
    see all
  • 功能
    Catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine.
  • 通路
    Carbohydrate metabolism; galactose metabolism.
  • 疾病相关
    Defects in GALE are the cause of epimerase-deficiency galactosemia (EDG) [MIM:230350]; also known as galactosemia type 3. Clinical features include early-onset cataracts, liver damage, deafness and mental retardation. There are two clinically distinct forms of EDG. (1) A benign, or 'peripheral' form with no detectable GALE activity in red blood cells and characterized by mild symptoms. Some patients may suffer no symptoms beyond raised levels of galactose-1-phosphate in the blood. (2) A much rarer 'generalized' form with undetectable levels of GALE activity in all tissues and resulting in severe features such as restricted growth and mental development.
  • 序列相似性
    Belongs to the sugar epimerase family.
  • Information by UniProt

图片

  • 15% SDS-PAGE showing ab96767 at approximately 40.4kDa (3µg).

文献

ab96767 has not yet been referenced specifically in any publications.

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