Recombinant人GADD45GIP1 protein (ab113863)

概述

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • AccessionQ8TAE8
    • 种属Human
    • 序列MGSSHHHHHHSSGLVPRGSHMPRWQLGPRYAAKQFARYGAASGVVPGSLW PSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAECMA KMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQ ELLQDLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASGAPSS
    • 分子量23 kDa including tags
    • 氨基酸48 to 222
    • 标签His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度> 90 % SDS-PAGE.
    ab113863 was purified by using conventional chromatography techniques.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 40% Glycerol, 0.03% DTT, 1.17% Sodium chloride

常规信息

  • 别名
    • 39S ribosomal protein L59 mitochondrial
    • CKBBP2
    • CKbetaBP2
    • CKII beta associating protein
    • CKII beta binding protein 2
    • CKII beta-associating protein
    • CR6 interacting factor 1
    • CR6-interacting factor 1
    • CRIF1
    • G45IP_HUMAN
    • Gadd45gip1
    • Growth arrest and DNA damage inducible GADD45G interacting protein
    • growth arrest and DNA damage inducible, gamma interacting protein 1
    • Growth arrest and DNA damage-inducible proteins-interacting protein 1
    • MGC4667
    • MGC4758
    • MRP L59
    • p53 responsive gene 6
    • p53 responsive gene 6 protein
    • p53-responsive gene 6 protein
    • Papillomavirus L2 interacting nuclear protein 1
    • Papillomavirus L2-interacting nuclear protein 1
    • PLINP
    • PLINP 1
    • PLINP-1
    • PLINP1
    • PRG6
    see all
  • 功能Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
  • 组织特异性Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.
  • 细胞定位Nucleus.
  • Information by UniProt

Recombinant Human GADD45GIP1 protein 图像

  • ab113863 at 3 µg analysed by 15% SDS-PAGE.

Recombinant Human GADD45GIP1 protein (ab113863)参考文献

ab113863 has not yet been referenced specifically in any publications.

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