Growth arrest and DNA damage inducible GADD45G interacting protein
growth arrest and DNA damage inducible, gamma interacting protein 1
Growth arrest and DNA damage-inducible proteins-interacting protein 1
p53 responsive gene 6
p53 responsive gene 6 protein
p53-responsive gene 6 protein
Papillomavirus L2 interacting nuclear protein 1
Papillomavirus L2-interacting nuclear protein 1
功能Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
组织特异性Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer.