Recombinant人G protein alpha inhibitor 1 (ab113585)

概述

描述

  • 性质
    Recombinant
  • 来源
    Escherichia coli
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      MGSSHHHHHHSSGLVPRGSHMGSMGCTLSAEDKAAVERSKMIDRNLREDG EKAAREVKLLLLGAGESGKSTIVKQMKIIHEAGYSEEECKQYKAVVYSNT IQSIIAIIRAMGRLKIDFGDSARADDARQLFVLAGAAEEGFMTAELAGVI KRLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYIPTQQDVLRT RVKTTGIVETHFTFKDLHFKMFDVGGQRSERKKWIHCFEGVTAIIFCVAL SDYDLVLAEDEEMNRMHESMKLFDSICNNKWFTDTSIILFLNKKDLFEEK IKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLNKRKDTKEIYTHFTCAT DTKNVQFVFDAVTDVIIKNNLKDCGLF
    • 分子量
      43 kDa including tags
    • 氨基酸
      1 to 354
    • 标签
      His tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab113585 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    SDS-PAGE

    Mass Spectrometry

  • 质谱法
    MALDI-TOF
  • 纯度
    > 90 % SDS-PAGE.
    ab113585 was purified using conventional chromatography.
  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

    pH: 8.00
    Constituents: 0.32% Tris HCl, 10% Glycerol

常规信息

  • 别名
    • Adenylate cyclase inhibiting G alpha protein
    • Adenylate cyclase inhibitory protein
    • Adenylate cyclase-inhibiting G alpha protein
    • G protein alpha inhibiting 1
    • G protein alpha inhibiting activity polypeptide 1
    • Gi
    • Gi inhibitory G protein
    • Gi1 protein alpha subunit
    • GNAI 1
    • GNAI1
    • GNAI1_HUMAN
    • Guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1
    • Guanine nucleotide binding protein alpha inhibiting activity polypeptide 1
    • Guanine nucleotide binding protein G(i) alpha 1 subunit
    • Guanine nucleotide-binding protein G(i) subunit alpha-1
    • OTTHUMP00000161319
    • OTTHUMP00000208047
    see all
  • 功能
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.
  • 序列相似性
    Belongs to the G-alpha family. G(i/o/t/z) subfamily.
  • 细胞定位
    Nucleus. Cytoplasm. Cell membrane. Cytoplasm > cytoskeleton > centrosome. Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody.
  • Information by UniProt

图片

  • 15% SDS-PAGE analysis of 3 µg ab113585.

文献

ab113585 has not yet been referenced specifically in any publications.

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