Recombinant人Fyn protein (ab85650)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab85650 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Sodium chloride, 50mM Tris HCl, 0.25mM DTT, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

常规信息

  • 别名
    • C syn protooncogene
    • Fyn
    • FYN oncogene related to SRC FGR YES
    • FYN_HUMAN
    • OKT3 induced calcium influx regulator
    • P59 FYN
    • p59-Fyn
    • Protein tyrosine kinase fyn
    • Proto oncogene tyrosine protein kinase fyn
    • Proto-oncogene c-Fyn
    • Proto-oncogene Syn
    • Protooncogene Syn
    • SLK
    • Src like kinase
    • Src yes related novel gene
    • Src-like kinase
    • Src/yes related novel
    • SYN
    • Tyrosine kinase p59fyn T
    • Tyrosine kinase p59fyn(T)
    • Tyrosine-protein kinase Fyn
    see all
  • 功能Tyrosine-protein kinase implicated in the control of cell growth. Plays a role in the regulation of intracellular calcium levels, with isoform 2 showing the greater ability to mobilize cytoplasmic calcium in comparison to isoform 1. Required in brain development and mature brain function with important roles in the regulation of axon growth, axon guidance, and neurite extension. Blocks axon outgrowth and attraction induced by NTN1 by phosphorylating its receptor DDC. Phosphorylates RUNX3.
  • 组织特异性Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T lymphocytes.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 细胞定位Cell membrane. Present and active in lipid rafts. Present in cell body and along the process of mature and developing oligodendroyctes.
  • Information by UniProt

Recombinant Human Fyn protein 图像

  • SDS-PAGE showing ab85650 at approximately 80kDa.

Recombinant Human Fyn protein (ab85650)参考文献

ab85650 has not yet been referenced specifically in any publications.

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