Recombinant人FRS2 protein (ab112397)

概述

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionQ8WU20
    • 种属Human
    • 序列MGSCCSCPDKDTVPDNHRNKFKVINVDDDGNELGSGIMELTDTELILYTR KRDSVKWHYLCLRRYGYDSNLFSFESGRRCQTGQGIFAFKCARAEELFNM LQEIMQNNSINVVEEPVVERNNHQTELEVPRTPRTPTTPGFAAQNLPNGY PRYPSFGDASSHPSSRHPSVGSARLPSVGEESTHPLLVAEEQVHTYVNTT GVQEERKNRTSVHVPLEARVSNAESSTPKEEPSSIEDRDPQILLEPEGVK FVLGPTPVQKQLMEKEKLEQLGRDQVSGSGANNTEWDTGYDSDERRDAPS VNKLVYENINGLSIPSASGVRRGRLTSTSTSDTQNINNSAQ
    • 分子量63 kDa including tags
    • 氨基酸1 to 341

技术指标

Our Abpromise guarantee covers the use of ab112397 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

    Other

  • 形式Liquid
  • 补充说明Best to use within three months from the date of receipt of this protein.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Glutathione is reduced.

常规信息

  • 别名
    • FGFR signaling adaptor SNT
    • FGFR signalling adaptor
    • FGFR substrate 2
    • FGFR-signaling adaptor SNT
    • Fibroblast growth factor receptor substrate 2
    • FRS 2
    • FRS2
    • FRS2_HUMAN
    • FRS2A
    • FRS2alpha
    • SNT
    • SNT 1
    • SNT-1
    • SNT1
    • Suc 1 Associated Neurotrophic Factor Target
    • Suc1 associated neurotrophic factor target 1
    • Suc1-associated neurotrophic factor target 1
    see all
  • 功能Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
  • 组织特异性Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
  • 序列相似性Contains 1 IRS-type PTB domain.
  • 翻译后修饰Phosphorylated on tyrosine residues upon stimulation by NGF.
    Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
  • 细胞定位Endomembrane system. Cytoplasmic, membrane-bound.
  • Information by UniProt

Recombinant Human FRS2 protein 图像

  • 12.5% SDS-PAGE analysis of ab112397. Stained with Coomassie Blue

Recombinant Human FRS2 protein (ab112397)参考文献

ab112397 has not yet been referenced specifically in any publications.

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