Recombinant人FRK protein (ab60861)

概述

描述

  • 性质Recombinant
  • 来源Baculovirus infected Sf9 cells
  • 氨基酸序列
    • 种属Human
    • 分子量60 kDa
    • 标签GST tag N-Terminus
    • 额外的序列信息Recombinant fragment, corresponding to amino acids 208-end of Human FRK.

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技术指标

Our Abpromise guarantee covers the use of ab60861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性

    Specific Activity: 997 nmol/min/mg.

  • 应用

    SDS-PAGE

    Functional Studies

  • 形式Liquid
  • 补充说明

    ab204877 (Poly (4:1 Glu, Tyr) peptide) can be utilized as a substrate for assessing kinase activity

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • Beta cell Src homology tyrosine kinase
    • BSK
    • BSK/IYK
    • C85044
    • Frk
    • Frk fyn related kinase
    • FRK_HUMAN
    • FYN related kinase
    • FYN-related kinase
    • GASK
    • Gastrointestinal associated kinase
    • Gastrointestinal associated tyrosine kinase
    • GTK
    • GTK, mouse, homolog of
    • Intestine tyrosine kinase
    • Nuclear tyrosine protein kinase RAK
    • Protein-tyrosine kinase 5
    • PTK5
    • PTK5 protein tyrosine kinase 5
    • RAK
    • Tyrosine protein kinase FRK
    • Tyrosine-protein kinase FRK
    see all
  • 功能Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
  • 组织特异性Restricted to cells lines derived from tissues of lymphoid, brain, breast, colon and bladder origin.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • 细胞定位Cytoplasm.
  • Information by UniProt

Recombinant human FRK protein 图像

  • Sample Kinase Activity Plot.
  • ab60861 on SDS-PAGE, MW ~60 kDa.

Recombinant human FRK protein (ab60861)参考文献

ab60861 has not yet been referenced specifically in any publications.

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