Recombinant人Frizzled 7 protein (ab112378)

常规信息

• 别名
  • Frizzled 7, seven transmembrane spanning receptor
  • frizzled class receptor 7
  • Frizzled drosophila homolog of 7

  • Frizzled family receptor 7
  • Frizzled homolog 7
  • Frizzled-7
  • Frizzled7
  • Fz 7
  • Fz-7
  • Fz7
  • FZD 7
  • FZD7
  • FZD7_HUMAN
  • FzE 3
  • FzE3
  • hFz 7
  • hFz7
  • Homolog of Drosophila Frizzled 7
  • OTTHUMP00000163742

  see all
• 功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
• 组织特异性High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
• 序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
  Contains 1 FZ (frizzled) domain.
• 结构域Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
  The FZ domain is involved in binding with Wnt ligands.
• 细胞定位Membrane.

• Target information above from: UniProt accession O75084 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt