概述
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产品名称重组人Frizzled 7蛋白
参阅全部 Frizzled 7 蛋白酶 -
蛋白长度Protein fragment
描述
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性质Recombinant
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来源Wheat germ
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氨基酸序列
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Accession
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种属Human
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序列GAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDLPFTALPPGASDGRGRP AFPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGLMYFKEEERRFA
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分子量37 kDa including tags
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氨基酸155 to 253
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技术指标
Our Abpromise guarantee covers the use of ab112378 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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生物活性This product is useful for Antibody Production and Protein Array
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应用
Western blot
ELISA
SDS-PAGE
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形式Liquid
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补充说明ab112378 is best used within three months from the date of receipt.This product is useful for Antibody Production and Protein Array
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 8.00
Constituents: 0.79% Tris HCl, 0.31% Glutathione
Note: Glutathione is reduced
常规信息
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别名
- Frizzled 7, seven transmembrane spanning receptor
- frizzled class receptor 7
- Frizzled drosophila homolog of 7
see all -
功能Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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组织特异性High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
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序列相似性Belongs to the G-protein coupled receptor Fz/Smo family.
Contains 1 FZ (frizzled) domain. -
结构域Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway.
The FZ domain is involved in binding with Wnt ligands. -
细胞定位Membrane.
- Information by UniProt
图片
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SDS-PAGE - Frizzled 7 protein (ab112378)ab112378 analysed by 12.5% SDS-PAGE and stained with Coomassie Blue.
文献
ab112378 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"