概述

描述

  • 性质
    Recombinant
  • 来源
    Wheat germ
  • 氨基酸序列
    • Accession
    • 种属
      Human
    • 序列
      KDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQ NSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRR
    • 分子量
      37 kDa including tags
    • 氨基酸
      74 to 172

技术指标

Our Abpromise guarantee covers the use of ab152388 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    ELISA

    Western blot

    SDS-PAGE

  • 形式
    Liquid
  • 补充说明
    Protein concentration is above or equal to 0.05 µg/µl.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.31% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • ARA
    • FKH L7
    • FKHL 7
    • FKHL7
    • Forkhead (Drosophila) like 7
    • Forkhead box C1
    • Forkhead box protein C1
    • Forkhead drosophila homolog like 7
    • Forkhead like 7
    • Forkhead related activator 3
    • Forkhead related protein FKHL7
    • Forkhead related transcription factor 3
    • Forkhead-related protein FKHL7
    • Forkhead-related transcription factor 3
    • FOX C1
    • FOXC 1
    • Foxc1
    • FOXC1_HUMAN
    • FREAC 3
    • FREAC-3
    • FREAC3
    • IGDA
    • IHG 1
    • IHG1
    • IRID 1
    • IRID1
    • Iridogoniodysgenesis type 1
    • Myeloid factor delta
    see all
  • 功能
    Binding of FREAC-3 and FREAC-4 to their cognate sites results in bending of the DNA at an angle of 80-90 degrees.
  • 组织特异性
    Expressed in all tissues and cell lines examined.
  • 疾病相关
    Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3 (RIEG3) [MIM:602482]; also known as Axenfeld-Rieger syndrome (ARS) or Axenfeld syndrome or Axenfeld anomaly. It is characterized by posterior corneal embryotoxon, prominent Schwalbe line and iris adhesion to the Schwalbe line. Other features may be hypertelorism (wide spacing of the eyes), hypoplasia of the malar bones, congenital absence of some teeth and mental retardation. When associated with tooth anomalies, the disorder is known as Rieger syndrome. Glaucoma is a progressive blinding condition that occurs in approximately half of patients with Axenfeld-Rieger malformations.
    Defects in FOXC1 are the cause of iridogoniodysgenesis anomaly (IGDA) [MIM:601631]. IGDA is an autosomal dominant phenotype characterized by iris hypoplasia, goniodysgenesis, and juvenile glaucoma.
    Defects in FOXC1 are a cause of Peters anomaly (PAN) [MIM:604229]. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.
  • 序列相似性
    Contains 1 fork-head DNA-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt

图片

  • 12.5% SDS-PAGE analysis of ab152388 stained with Coomassie Blue.

文献

ab152388 has not yet been referenced specifically in any publications.

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