Recombinant人FLAP protein (ab114639)

概述

  • 产品名称Recombinant人FLAP protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionP20292
    • 种属Human
    • 序列MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAF ERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVG YLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTI STTISPLLLIP
    • 分子量43 kDa including tags
    • 氨基酸1 to 161

技术指标

Our Abpromise guarantee covers the use of ab114639 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    ELISA

    SDS-PAGE

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.3% Glutathione, 0.79% Tris HCl

常规信息

  • 别名
    • 5-lipoxygenase activating protein
    • AL5AP_HUMAN
    • ALOX 5AP
    • ALOX5 AP
    • ALOX5AP
    • Arachidonate 5 lipoxygenase activating protein
    • Arachidonate 5-lipoxygenase-activating protein
    • Five lipoxygenase activating protein
    • FLAP
    • MK 886 binding protein
    • MK-886-binding protein
    see all
  • 功能Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
  • 疾病相关Genetic variations in ALOX5AP may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Note=Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (PubMed:14770184), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other (PubMed:17304054) ALOX5AP is not implicated in this condition.
  • 序列相似性Belongs to the MAPEG family.
  • 结构域The C-terminal part after residue 140 is mostly unstructured.
  • 细胞定位Nucleus membrane. Endoplasmic reticulum membrane.
  • Information by UniProt

Recombinant Human FLAP protein 图像

  • 12.5% SDS-PAGE image showing ab114639 Stained with Coomassie Blue.

Recombinant Human FLAP protein (ab114639)参考文献

ab114639 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab114639.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"