Recombinant人Fibronectin Fragment III.1 protein (ab58865)

概述

  • 产品名称Recombinant人Fibronectin Fragment III.1 protein
  • 蛋白长度Protein fragment

描述

  • 性质Recombinant
  • 来源Escherichia coli
  • 氨基酸序列
    • 种属Human

技术指标

Our Abpromise guarantee covers the use of ab58865 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度> 95 % SDS-PAGE.

  • 形式Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C.

    Preservative: None

  • 复溶Reconstitute with 0.5 ml of sterile PBS per 0.5 mg vial. The stock solution can be further diluted with sterile PBS or cell culture medium.

常规信息

  • 别名
    • CIG
    • Cold insoluble globulin
    • Fibronectin 1
    • Fibronectin precursor
    • FINC
    • FN
    • LETS
    • Migration stimulating factor
    • MSF
    see all
  • 相关性Fibronectins are made of two subunits linked by disulfide bonds at the C terminal. In the extracellular matrix fibrils, fibronectins are further disulfide bonded into high molecular weight polymers. Fibronectin subunits vary in size between approximately 235 and 270 kDa depending on tissue and species. Each subunit is made of repeating modules of three types: I, II, and III. There are 12 type I repeats, approximately 45 amino acids long, clustered in three groups, two adjacent type II repeats each 60 amino acids long, and 15-17 type III repeats each about 90 amino acids long. Type I and type II each contains two disulfide bonds, while type III lacks disulfide bonds. There are two free sulfhydryl groups per subunit at the type III repeat. Recombinant fragment III1-C, modeled after the C-terminal two-thirds of the III1 repeat, was found to bind to fibronectin and induce spontaneous disulfide crosslinking of the fibronectin molecules into multimers, which resemble matrix fibrils.(Moria, A., et al., Nature, 367, 193 (1994).
  • 细胞定位Secreted protein; extracellular space; extracellular matrix

Recombinant Human Fibronectin Fragment III.1 protein (ab58865)参考文献

ab58865 has not yet been referenced specifically in any publications.

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