This product is an active protein and may elicit a biological response in vivo, handle with caution.
Fibroblast growth factor receptor 4
Hydroxyaryl protein kinase
Protein tyrosine kinase
Tyrosine kinase related to fibroblast growth factor receptor
功能Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.
组织特异性Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 protein kinase domain.
翻译后修饰Glycosylated. Phosphorylated on tyrosine residue (By similarity). Phosphorylation requires the presence of a functional (phosphorylated) FGFR1 and not necessarily by means of FGFR heterodimerization.