Recombinant人FGFR1 protein (Fc Chimera) (ab73508)

概述

描述

  • 性质Recombinant
  • 来源Insect cells
  • 氨基酸序列
    • 种属Human
    • 分子量170 kDa
    • 额外的序列信息Fused with the Fc part of human IgG1 at the Xa cleavage site.

技术指标

Our Abpromise guarantee covers the use of ab73508 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性

    Determined by its ability to inhibit human FGF acidic-dependent proliferation on R1 cells. The ED50 for this effect is typically at 15.0-30.0 ng/ml.

  • 应用

    Functional Studies

    SDS-PAGE

  • 纯度> 90 % SDS-PAGE.
    This protein was purified by proprietary chromatographic techniques. Purity: Greater than 90.0% as determined by: (a)Analysis by RP-HPLC. (b)Analysis by SDS-PAGE.
  • 形式Lyophilised
  • 补充说明

    For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

    Alternative splicing of FGFR1 and FGFR2 mRNAs results in receptors containing all three Ig domains, referred to as the alpha isoform, or only IgII and IgIII, referred to as the beta isoform. Differential splicing for FGFR1 to FGFR3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generates FGF receptors with alternative IgIII domains (IIIb and IIIc).

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.

    Preservative: None
    No additives

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

  • 复溶Reconstitute in sterile PBS not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

常规信息

  • 别名
    • Basic fibroblast growth factor receptor 1
    • bFGF-R-1
    • BFGFR
    • CD331
    • CEK
    • FGFBR
    • FGFR 1
    • FGFR-1
    • FGFR1
    • FGFR1/PLAG1 fusion
    • FGFR1_HUMAN
    • fibroblast growth factor receptor 1
    • FLG
    • FLT-2
    • FLT2
    • Fms-like gene
    • Fms-like tyrosine kinase 2
    • fms-related tyrosine kinase 2
    • HBGFR
    • heparin-binding growth factor receptor
    • HH2
    • HRTFDS
    • hydroxyaryl-protein kinase
    • KAL2
    • N-SAM
    • OGD
    • Proto-oncogene c-Fgr
    see all
  • 功能Receptor for basic fibroblast growth factor. Receptor for FGF23 in the presence of KL (By similarity). A shorter form of the receptor could be a receptor for FGF1 (aFGF).
  • 组织特异性Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.
  • 疾病相关Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
    Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.
    Defects in FGFR1 are the cause of Kallmann syndrome type 2 (KAL2) [MIM:147950]; also known as hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some cases, midline cranial anomalies (cleft lip/palate and imperfect fusion) are present and anosmia may be absent or inconspicuous.
    Defects in FGFR1 are the cause of osteoglophonic dysplasia (OGD) [MIM:166250]; also known as osteoglophonic dwarfism. OGD is characterized by craniosynostosis, prominent supraorbital ridge, and depressed nasal bridge, as well as by rhizomelic dwarfism and nonossifying bone lesions. Inheritance is autosomal dominant.
    Defects in FGFR1 are the cause of trigonocephaly non-syndromic (TRICEPH) [MIM:190440]; also known as metopic craniosynostosis. The term trigonocephaly describes the typical keel-shaped deformation of the forehead resulting from premature fusion of the frontal suture. Trigonocephaly may occur also as a part of a syndrome.
    Note=A chromosomal aberration involving FGFR1 may be a cause of stem cell leukemia lymphoma syndrome (SCLL). Translocation t(8;13)(p11;q12) with ZMYM2. SCLL usually presents as lymphoblastic lymphoma in association with a myeloproliferative disorder, often accompanied by pronounced peripheral eosinophilia and/or prominent eosinophilic infiltrates in the affected bone marrow.
    Note=A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(6;8)(q27;p11) with FGFR1OP. Insertion ins(12;8)(p11;p11p22) with FGFR1OP2. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion proteins FGFR1OP2-FGFR1, FGFR1OP-FGFR1 or FGFR1-FGFR1OP may exhibit constitutive kinase activity and be responsible for the transforming activity.
    Note=A chromosomal aberration involving FGFR1 may be a cause of stem cell myeloproliferative disorder (MPD). Translocation t(8;9)(p12;q33) with CEP110. MPD is characterized by myeloid hyperplasia, eosinophilia and T-cell or B-cell lymphoblastic lymphoma. In general it progresses to acute myeloid leukemia. The fusion protein CEP110-FGFR1 is found in the cytoplasm, exhibits constitutive kinase activity and may be responsible for the transforming activity.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 1 protein kinase domain.
  • 翻译后修饰Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.
  • 细胞定位Membrane. Nucleus. Cytoplasm. Cytoplasmic vesicle
  • Information by UniProt

Recombinant human FGFR1 protein (Fc Chimera) (ab73508)参考文献

ab73508 has not yet been referenced specifically in any publications.

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