The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ab108946 activates ERK and FRS2a phosphorylation in Rat hepatoma cells.
< 0.100 Eu/µg
% SDS-PAGE. ab108946 is 0.2µm filtered.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
This product is an active protein and may elicit a biological response in vivo, handle with caution.
Fibroblast growth factor 15
Fibroblast growth factor 19
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Belongs to the heparin-binding growth factors family.
ERK and FRS2a phosphorylation induced by FGF19 in Rat hepatoma cells.
H4IIE Rat hepatoma cells were serum starved for 16hr and then stimulated with FGF-21-Fc or FGF-b (100ng/ml) (positive control) for 10 min, respectively. Antibodies against pFRS2a, pERK1/2 & total ERK1/2 were used for immunoblotting.
Lane 1: control (non-treated)
Lane 2: 30ng/ml hFGF19-His
Lane 3: 100ng/ml hFGF19-His
Lane 4: 300ng/ml hFGF19-His
Lane 5: 1000ng/ml hFGF19-His
Lane 6: 100ng/ml FGF-b
Recombinant human FGF19 protein (ab108946)参考文献
has not yet been referenced specifically in any publications.