Recombinant人FGF19 protein (ab108946)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • AccessionO95750
    • 种属Human
    • 分子量28 kDa including tags
    • 氨基酸1 to 216
    • 标签His tag C-Terminus

技术指标

Our Abpromise guarantee covers the use of ab108946 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性ab108946 activates ERK and FRS2a phosphorylation in Rat hepatoma cells.
  • 应用

    Functional Studies

    SDS-PAGE

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 90 % SDS-PAGE.
    ab108946 is 0.2µm filtered.
  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: PBS

    This product is an active protein and may elicit a biological response in vivo, handle with caution.

常规信息

  • 别名
    • FGF 19
    • FGF-19
    • FGF15
    • FGF19
    • FGF19_HUMAN
    • Fibroblast growth factor 15
    • Fibroblast growth factor 19
    see all
  • 功能Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB.
  • 组织特异性Expressed in fetal brain, cartilage, retina, and adult gall bladder.
  • 序列相似性Belongs to the heparin-binding growth factors family.
  • 细胞定位Secreted.
  • Information by UniProt

Recombinant human FGF19 protein 图像

  • ERK and FRS2a phosphorylation induced by FGF19 in Rat hepatoma cells. H4IIE Rat hepatoma cells were serum starved for 16hr and then stimulated with FGF-21-Fc or FGF-b (100ng/ml) (positive control) for 10 min, respectively. Antibodies against pFRS2a, pERK1/2 & total ERK1/2 were used for immunoblotting.
    Lane 1: control (non-treated)
    Lane 2: 30ng/ml hFGF19-His
    Lane 3: 100ng/ml hFGF19-His
    Lane 4: 300ng/ml hFGF19-His
    Lane 5: 1000ng/ml hFGF19-His
    Lane 6: 100ng/ml FGF-b

Recombinant human FGF19 protein (ab108946)参考文献

ab108946 has not yet been referenced specifically in any publications.

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