Recombinant人Fas Ligand protein (ab109359)

概述

描述

  • 性质Recombinant
  • 来源HEK 293 cells
  • 氨基酸序列
    • AccessionP48023
    • 种属Human
    • 序列QLFHLQKELAELRESTSQMHTASSLEKQIGHPSPPPEKKELRKVAHLTGK SNSRSMPLEWEDTYGIVLLSGVKYKKGGLVINETGLYFVYSKVYFRGQSC NNLPLSHKVYMRNSKYPQDLVMMEGKMMSYCTTGQMWARSSYLGAVFNLT SADHLYVNVSELSLVNFEESQTFFGLYKL
    • 分子量33 kDa including tags
    • 氨基酸103 to 281
    • 标签DDDDK tag N-Terminus

技术指标

Our Abpromise guarantee covers the use of ab109359 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 生物活性Induces apoptosis of Jurkat T cells at a concentration of <1ng/ml in the presence of 0.1 to 1µg/ml TNF Ligand enhancer. In the absence of TNF Ligand enhancer ab109359 is working at 50-100 fold higher concentrations.
  • 应用

    SDS-PAGE

    Functional Studies

  • 内毒素水平< 0.100 Eu/µg
  • 纯度> 95 % SDS-PAGE.
    ab109359 can bind to human and mouse Fas.
  • 形式Lyophilised
  • 补充说明 Induces apoptosis of Jurkat T cells at a concentration of <1ng/ml in the presence of 0.1 to 1µg/ml TNF Ligand enhancer. In the absence of TNF Ligand enhancer ab109359 is working at 50-100 fold higher concentrations.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

    Preservative: None
    Constituents: PBS

  • 复溶Reconstitute with 100µl sterile water. PBS containing at least 0.1% BSA should be used for further dilutions.

常规信息

  • 别名
    • ALPS1B
    • Apoptosis (APO 1) antigen ligand 1
    • Apoptosis antigen ligand
    • Apoptosis antigen ligand 1
    • APT1LG1
    • APTL
    • CD178
    • CD178 antigen
    • CD95 ligand
    • CD95-L
    • CD95L
    • CD95L protein
    • Fas antigen ligand
    • Fas L
    • Fas ligand
    • Fas ligand (TNF superfamily member 6)
    • FASL
    • Fasl Fas ligand (TNF superfamily member 6)
    • FASLG
    • Generalized lymphoproliferative disease
    • Gld
    • soluble form
    • TNFL6_HUMAN
    • TNFSF6
    • Tumor necrosis factor (ligand) superfamily member 6
    • Tumor necrosis factor ligand superfamily member 6
    see all
  • 功能Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects.
  • 疾病相关Defects in FASLG are the cause of autoimmune lymphoproliferative syndrome type 1B (ALPS1B) [MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly.
  • 序列相似性Belongs to the tumor necrosis factor family.
  • 翻译后修饰N-glycosylated.
    The soluble form derives from the membrane form by proteolytic processing.
  • 细胞定位Cell membrane. Secreted. May be released into the extracellular fluid, probably by cleavage form the cell surface.
  • Information by UniProt

Recombinant Human Fas Ligand protein (ab109359)参考文献

ab109359 has not yet been referenced specifically in any publications.

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