Recombinant人FANCG protein (ab114925)

概述

  • 产品名称Recombinant人FANCG protein
  • 蛋白长度Full length protein

描述

  • 性质Recombinant
  • 来源Wheat germ
  • 氨基酸序列
    • AccessionO15287
    • 种属Human
    • 序列MSRQTTSVGSSCLDLWREKNDRLVRQAKVAQNSGLTLRRQQLAQDALE GLRGLLHSLQGLPAAVPVLPLELTVTCNFIILRASLAQGFTEDQAQDIQR SLERVLETQEQQGPRLEQGLRELWDSVLRASCLLPELLSALHRLVGLQAA LWLSADRLGDLALLLETLNGSQSGASKDLLLLLKTWSPPAEELDAPLTLQ DAQGLKDVLLTAFAYRQGLQELITGNPDKALSSLHEAASGLCPRPVLVQV YTALGSCHRKMGNPQRALLYLVAALKEGSAWGPPLLEASRLYQQLGDTTA ELESLELLVEALNVPCSSKAPQFLIEVELLLPPPDLASPLHCGTQSQTKH ILASRCLQTGRAGDAAEHYLDLLALLLDSSEPRFSPPPSPPGPCMPEVFL EAAVALIQAGRAQDALTLCEELLSRTSSLLPKMSRLWEDARKGTKELPYC PLWVSATHLLQGQAWVQLGAQKVAISEFSRCLELLFRATPEEKEQGAAFN CEQGCKSDAALQQLRAAALISRGLEWVASGQDTKALQDFLLSVQMCPGNR DTYFHLLQTLKRLDRRDEATALWWRLEAQTKGSHEDALWSLPLYLESYLS WIRPSDRDAFLEEFRTSLPKSCDL
    • 分子量95 kDa including tags
    • 氨基酸1 to 622

技术指标

Our Abpromise guarantee covers the use of ab114925 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Western blot

    SDS-PAGE

    ELISA

  • 形式Liquid
  • 补充说明Protein concentration is above or equal to 0.05 mg/ml.
    This protein is best used within three months from the date of receipt.
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.

    pH: 8.00
    Constituents: 0.79% Tris HCl, 0.3% Glutathione

常规信息

  • 别名
    • DNA repair protein XRCC9
    • FAG
    • FANCG
    • FANCG_HUMAN
    • Fanconi anaemia complementation group G
    • Fanconi anemia group G protein
    • Protein FACG
    • X ray repair, complementing defective, in Chinese hamster cells 9
    • X-ray repair, complementing defective, in Chinese hamster, 9
    • XRCC9
    see all
  • 功能DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.
  • 组织特异性Highly expressed in testis and thymus. Found in lymphoblasts.
  • 疾病相关Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.
  • 序列相似性Contains 4 TPR repeats.
  • 细胞定位Nucleus. Cytoplasm. The major form is nuclear. The minor form is cytoplasmic.
  • Information by UniProt

Recombinant Human FANCG protein 图像

  • 12.5% SDS-PAGE showing ab114925 at approximately 94.53kDa.
    Stained with Coomassie Blue.

Recombinant Human FANCG protein (ab114925)参考文献

ab114925 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"