The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
% SDS-PAGE. ab89242 is purified using conventional chromatography techniques.
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Constituents: 10% Glycerol, 20mM Tris HCl, pH 8.0
Fas (TNFRSF6) associated via death domain
Fas associated via death domain
Fas associating death domain containing protein
Fas associating protein
Fas associating protein with death domain
Fas TNFRSF6 associated via death domain
FAS-associated death domain protein
FAS-associating death domain-containing protein
Growth inhibiting gene 3 protein
Growth-inhibiting gene 3 protein
H sapiens mRNA for mediator of receptor induced toxicity
Mediator of receptor induced toxicity
功能Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
组织特异性Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
序列相似性Contains 1 death domain. Contains 1 DED (death effector) domain.
结构域Contains a death domain involved in the binding of the corresponding domain within Fas receptor.