H sapiens mRNA for mediator of receptor induced toxicity
Mediator of receptor induced toxicity
Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.
Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Contains 1 death domain. Contains 1 DED (death effector) domain.
Contains a death domain involved in the binding of the corresponding domain within Fas receptor.